FUNCTIONAL ROLE OF N-LINKED GLYCOSYLATION IN HUMAN HEPATIC LIPASE: ASPARAGINE-56 IS IMPORTANT FOR BOTH ENZYME ACTIVITY AND SECRETION.

Functional role of N-linked glycosylation in human hepatic lipase: asparagine-56 is important for both enzyme activity and secretion.

Hepatic lipase (HL) and lipoprotein lipase (LPL) are evolutionarily related enzymes that are essential for normal lipoprotein metabolism.While much has been published on the structure-function relationship of LPL, little is known concerning the structural basis of HL action and secretion.Human HL is a glycoprotein and its predicted amino acid seque

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Non-Structural Carbohydrate Content and C:N:P Stoichiometry in Houpoea officinalis Flowers in Response to Development Stages

Mineral elements and non-structural carbohydrates (NSCs) are important nutrients and energy sources for flower development in plants.However, no studies were reported on the dynamic changes of nutrient stoichiometry and NSC contents in Houpoea officinalis (H.officinalis) flower.In this study, the changes in carbon (C), nitrogen (N), phosphorus (P),

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The Hippo Signaling Pathway Manipulates Cellular Senescence

The Hippo pathway, a kinase cascade, coordinates with many intracellular signals and mediates the regulation of the activities of various downstream transcription factors and Costumes their coactivators to maintain homeostasis.Therefore, the aberrant activation of the Hippo pathway and its associated molecules imposes significant stress on tissues

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Reconstruction and validation of ground motions across dip-slip faults: an application to response analysis of a long-span suspension bridge

Abstract Recent seismic events have unequivocally highlighted the susceptibility of fault-crossing bridges to the synergistic effects of ground surface vibrations on either side of the fault plane and the tectonic dislocations arising from fault-induced surface ruptures.This MOISTURIZING CONDITIONER study delineates both seismic and parametric resp

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